Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Inside Cover: Multiplication of Human Natural Killer Cells by Nanosized Phosphonate-Capped Dendrimers (Angew. Chem. Int. Ed. 14/2007)
Human peripheral blood mononuclear cells (white blood cells) cultured in the presence of dendrimers capped with phosphonate groups reveal a selective multiplication of natural killer (NK) cells. In their Communication on page 2523 ff., A.-M. Caminade, R. Poupot, J.-P. Majoral, and co-workers describe the synthesis of various phosphazene dendrimers and their effect on NK cells, which play a key role in anticancer immunity. The picture shows a fluorescence microscopy image of a NK cell (red) engaged with target cancer cells (green).