Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 31

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

46_20b/2007Inside Cover: Hydrogen Peroxide Dependent Monooxygenations by Tricking the Substrate Recognition of Cytochrome P450BSβ (Angew. Chem. Int. Ed. 20/2007)

A clever trick to change the substrate specificity of hydrogen peroxide dependent cytochrome P450 (P450BSβ) without replacing any amino acid residues is described by Y. Watanabe and co-workers in their Communication on page 3656 ff. Substrate misrecognition is induced by a decoy molecule with a structure similar to that of the natural substrate. Several oxidation reactions of nonnatural substrates, such as the hydroxylation of ethylbenzene, are demonstrated with this system.

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