Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 14

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

46_23b/2007Inside Cover: Total Synthesis of the Potent Antitumor Macrolides Pladienolide B and D (Angew. Chem. Int. Ed. 23/2007)

Pladienolides, 12-membered macrolides isolated from Streptomyces platensis Mer-11107, show prominent in vitro and in vivo antitumor activities based on a unique mode of action. Y. Kotake and co-workers describe in their Communication on page 4350 ff. the first total synthesis of this class of natural product, by an efficient coupling between macrolide and side-chain fragments, which confirmed the absolute structure and provided a practical method to prepare analogues.

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