Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Inside Cover: Total Synthesis of the Potent Antitumor Macrolides Pladienolide B and D (Angew. Chem. Int. Ed. 23/2007)
Pladienolides, 12-membered macrolides isolated from Streptomyces platensis Mer-11107, show prominent in vitro and in vivo antitumor activities based on a unique mode of action. Y. Kotake and co-workers describe in their Communication on page 4350 ff. the first total synthesis of this class of natural product, by an efficient coupling between macrolide and side-chain fragments, which confirmed the absolute structure and provided a practical method to prepare analogues.