Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 40

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

46_27/2007Cover Picture: Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2 (Angew. Chem. Int. Ed. 27/2007)

Hippocrates (the father of medicine) described the healing properties of St. John's wort 2500 years ago and prescribed it for the treatment of depression. Hyperforin, which is considered to be responsible for this activity, also has anticancer, antibacterial, and wound-healing activity. A. Giannis et al. describe in their Communication on page 5219 ff. that hyperforin and two related compounds are inhibitors of sirtuins SIRT1 and SIRT2. This property could explain some of the pharmacological properties of hyperforin.

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Also of Interest

Ansa Complexesfor001

In their Review on page 5060 ff., I. Manners and co-workers describe the synthesis and properties of strained metallocenophanes and related compounds, some of which undergo insertions and ring-opening polymerization under the right conditions.


Numerous polyferrocenylsilane materials with exceptional physical properties and functions are accessible through ring-opening polymerization, as M. Rehahn and V. Bellas summarize in their Review on page 5082 ff.

Fluorinated Carbocyclesfor003

Reversal is the trump card when the traditional approach to fluorinated ring systems by Diels–Alder reaction and subsequent fluorination fails. In their Communication on page 5105 ff, V. Gouverneur et al. show how inverting the two steps solves selectivity issues.