Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 23

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

46_48b/2007Inside Cover: Total Synthesis and Configurational Assignment of Pasteurestin A and B (Angew. Chem. Int. Ed. 48/2007)

Application in veterinary medicine was proposed for the sesquiterpenoids pasteurestins A and B because of their strong and selective activity against Pasteurella haemolytica. A Vollhardt [2+2+2] cycloaddition was the key step in their total synthesis, which is described by J. Mulzer et al. on page 9320 ff., and subsequently their absolute and relative configurations could be established and their biological activities more precisely specified. Another feature of the synthesis of pasteurestin B is a tin(II) enolate mediated Reformatsky-type condensation.

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