Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Increasing the Complexity of Periodic Protein Nanostructures by the Rolling-Circle-Amplified Synthesis of Aptamers (Angew. Chem. Int. Ed. 1/2008)
A self-inking roller can be used to print an extended strip with periodic repeating units. In the same way, by the biochemical technique of rolling-circle amplification (RCA), a circular oligonucleotide sequence serves as a template for the synthesis of a complementary single-stranded DNA chain. If the DNA chain contains aptamers for a protein such as thrombin or lysozyme, subsequent complexation results in periodic protein–DNA composites. I. Willner et al. describe such compounds and even assemblies of DNA, protein, and gold nanoparticles on pp. 126 ff.
Also of Interest
In their Minireview on page 48 ff., S. L. Schreiber and T. E. Nielson discuss the three phases of the build/couple/pair strategy for the efficient synthesis of stereochemically and skeletally diverse small molecules.
The prospects offered by solar cells based on organic polymers and fullerenes are described by J. M. J. Fréchet and B. C. Thompson in their Review on page 58 ff.
K. A. Wheeler et al. reconstruct Pasteur's 1853 account of peculiar three-component crystals in their Communication on page 78 ff. They were able to confirm the identities of the two crystalline phases as ammonium (+)-bitartrate and a quasiracemate of ammonium (+)-bitartrate/(−)-bimalate.