Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 52

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

47_05/2008Cover Picture: DNA Minicircles with Gaps for Versatile Functionalization / Construction of DNA Architectures with RNA Hairpins (Angew. Chem. Int. Ed. 5/2008)

Bind the gap ...... The cover picture shows an idealized rendering of a DNA minicircle (green) with a 21-nucleotide-long single-stranded region, or gap. M. Famulok and co-workers show in their Communication on page 967 ff. how these circles can be generated and visualized by atomic force microscopy. Any complementary oligonucleotide (red) can hybridize to the gap so that synthetic functional groups can be incorporated. In a second study on page 971 ff. they show that RNA molecules can also hybridize to form a heteroduplex with the gap, enabling the incorporation of nucleic acid motifs in DNA minicircles.

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Also of Interest

The Influence of Olefinsfor001

The activity, stability, or selectivity of catalytic reactions, in particular cross-coupling reactions, can be significantly influenced by olefin components, as T. Rovis and J. B. Johnson show with many examples in their Review on page 840 ff.

Molecular Logic Gatesfor002

J. Yoon, S. Park, et al. describe in their Communication on page 872 ff. a programmable microfluidic device based on chemosensors which change their fluorescence intensity in response to various inputs, such as pH value.

Tin Ligandsfor003

In their Communication on page 963 ff. L. Wesemann et al. report that in their negatively charged complexes with the tin ligand stanna-closododecaborate, Ni, Pd, and Pt centers have high coordination numbers and high formal oxidation states.