Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 14

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

47_07/2008Cover Picture: Chemistry and Biology of the Aeruginosin Family of Serine Protease Inhibitors (Angew. Chem. Int. Ed. 7/2008)

Different phyla and different oceans are sources of linear peptides in the aeruginosin family which comprise a central hydroxy- (or dihydroxy-) octahydroindole carboxamide core unit onto which unusual amino acids are appended. The aeruginosins exhibit varying degrees of inhibitory activity against serine proteases, including factor II (thrombin) and factor VIIa of the blood coagulation cascade. In their Review on page 1202 ff., S. Hanessian et al. provide an overview of the chemical and biological properties of the aeruginosins as well as the natural sources of these compounds, their total syntheses, and structure revisions.

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Fluorescent Dyesfor001

Bodipy dyes, which were originally developed as luminescent tags and laser dyes, are well-suited for organic electronic materials and nanotechnology. In the Minireview on page 1184 ff., R. Ziessel and co-workers discuss this class of compounds.


Pulse EPR Spectroscopyfor002

In their Communication on page 1224 ff., M. Bennati et al. describe the use of pulse EPR at high frequencies for the determination of both the distance between and the relative orientation of tyrosyl radicals within protein complexes.


Chiral Amplificationfor003

In the Communication on page 1232 ff., F. Würthner and A. Lohr explain which factors are important for the homochirogenesis by self-assembly of bis(merocyanine) dyes.


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