Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 36

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

47_09/2008Cover Picture: Tip-Enhanced Raman Spectroscopy of Single RNA Strands: Towards a Novel Direct-Sequencing Method (Angew. Chem. Int. Ed. 9/2008)

Tip-enhanced Raman spectroscopy (TERS) provides high lateral resolution, down to a few nucleobases in a single RNA strand of a cytosine homopolymer. A silver-coated nanotip which can be positioned with high precision serves as a Raman enhancer. TERS spectra are obtained by positioning the tip along the RNA strand. As E. Bailo and V. Deckert show in their Communication on page 1658 ff., the sensitivity obtained suggests that, with TERS, the direct and label-free sequencing of biomolecules, such as DNA, RNA, or peptides, is feasible.

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Also of Interest

Lewis Base Catalysisfor001

The Review by S. E. Denmark and G. L. Beutner on page 1560 ff. introduces a new conceptual framework for Lewis base catalysis. The many applications of Lewis bases as catalysts are illustrated for numerous examples of different reactions.

Microporous Materialsfor002

The intercalation of a molecular spacer into synthetic Cs-tainiolite provides a size- and shape-selective microporous material that displays electric conductivity, as demonstrated by J. Breu et al. in their Communication on page 1640 ff.

Peptidic Catalystsfor003

M. R. Ghadiri and co-workers have designed modular supramolecular catalysts with a coiled-coil peptide scaffold that catalyze the formation of diketopiperazines and linear dipeptides from a range of aminoacyl substrates. More information can be found in their Communication on page 1758 ff.