Angewandte Chemie International Edition
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Inside Cover: Periodic Iron Nanomineralization in Human Serum Transferrin Fibrils (Angew. Chem. Int. Ed. 12/2008)
Periodic iron mineralization in human serum transferrin fibrils has been observed by microscopy, as described by P. J. Sadler, S. Verma, and co-workers in the Communication on page 2217 ff. The picture shows transferrin as a ribbon structure, typical micrographs of the fibers, and the diffraction pattern of a fiber nanocrystallite (which resembles the iron oxide/hydroxide mineral shown in a space-filling representation). These findings suggest a previously unknown biological role for transferrin.