Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Inside Cover: Total Synthesis of (±)-Axinellamines A and B (Angew. Chem. Int. Ed. 19/2008)
Chemoselective by design is the total synthesis of marine pyrrole–imidazole alkaloids of the axinellamine/palau'amine/massadine class described by P. S. Baran and co-workers in their Communication on page 3581 ff. Their approach features unconventional transformations on completely unprotected polyamino and hydroxylated substrates and a new method for chemoselective oxidations in such settings.