Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: PdII-Catalyzed Enantioselective Activation of C(sp2)-H and C(sp3)-H Bonds Using Monoprotected Amino Acids as Chiral Ligands (Angew. Chem. Int. Ed. 26/2008)
Gearing between the α carbon atom and the nitrogen atom of an amino acid relays chiral information to the palladium(II) center, which cleaves C-H bonds asymmetrically. In their Communication on page 4882 ff., J.-Q. Yu et al. report on the palladium(II)-catalyzed enantioselective alkylation of sp2 and sp3 C-H bonds with boronic acids.
Also of Interest
Hydrogen Abstraction and Electron Transfer
Aminoxyl radicals can participate in a chemical reaction in two ways: by hydrogen atom transfer (HAT) or by electron-transfer (ET). The preferred mechanism depends on the substrate and the redox potential of the radicals, as C. Galli et al. explain in their Minireview on page 4790 ff.
A huge variety of compounds with open-framework structures can be prepared through the use of different inorganic oxo anions. The syntheses and properties of these structures are described by S. Natarajan and S. Mandal in their Review on page 4798 ff.
Nanoconjugate Drug Delivery Vehicles
Drug release can be controlled when the active compound is integrated into a polymer nanoparticle, as J. Cheng and R. Tong show in their Communication on page 4830 ff.