Angewandte Chemie International Edition
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Inside Cover: Chemical Tags Facilitate the Sensing of Individual DNA Strands with Nanopores (Angew. Chem. Int. Ed. 30/2008)
Chemical tags help detect separate bases in individual DNA strands, as demonstrated by S. Howorka and N. Mitchell in the Communication on page 5565 ff. In the sensing strategy, a single DNA strand is threaded through a “nanotunnel”. Owing to their larger diameter, individual bases with attached chemical tags are slowed at the narrow constriction. The pattern of modified and unmodified bases gives rise to a characteristic current signal for the DNA. The picture was prepared by Hugh Martin.