Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: The Continuing Saga of the Marine Polyether Biotoxins (Angew. Chem. Int. Ed. 38/2008)
An odyssey is described by K. C. Nicolaou et al. in their Review on page 7182 ff.: From the isolation of the first marine biotoxin with a ladder structure, brevetoxin B, in 1981 to the synthesis of maitotoxin molecule domains. Pictured is the dinoflagellate Gambierdiscus toxicus (small circle; courtesy of Steve L. Morton, NOAA), a unicellular marine organism producing maitotoxin, the largest and most toxic, non-proteomic secondary metabolite isolated to date. The surgeonfish (moodboard/Corbis) serves as a carrier of this neurotoxin to humans through the food chain causing ciguatera poisoning.
Also of Interest
B. Kaptein et al. show in their Communication on page 7226 ff. that small enantiomeric excesses can be amplified by grinding solid enantiomeric mixtures of a phenylalanine derivative in near-equilibrium with a saturated solution in which racemization takes place.
In their Appeal on page 7164 ff. R. Hoffmann, P. von R. Schleyer, and H. F. Schaefer III examine the terminology used to describe hypothetical molecules predicted by using computational methods.
Criteria such as reliability and predictive validity were used to assess the peer review process at Angewandte Chemie. The results of the study by L. Bornmann and H.-D. Daniel are reported in their Essay on page 7173 ff., and include a comparison to a similar study which was done in the mid-1980's.