Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 41

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

47_41b/2008Inside Cover: Gold(I)-Catalyzed Alkoxyhalogenation of β-Hydroxy-α,α-Difluoroynones (Angew. Chem. Int. Ed. 41/2008)

Gold(I) catalysts teamed with selectfluor produce trifluorinated dihydropyranones from difluoroynones under mild conditions, as described by V. Gouverneur et al. in the Communication on page 7927 ff. The process proceeds via a vinylgold intermediate that undergoes fluorination and competing protonation. This gold chemistry is encouraging for the synthesis of architecturally complex fluorinated targets combining fluorinated precursors with electrophilic fluorinating reagents. The illustration was produced by Dr. Karl Harrison (University of Oxford)

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