Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Organocatalytic Asymmetric Inverse-Electron-Demand Aza-Diels–Alder Reaction of N-Sulfonyl-1-aza-1,3-butadienes and Aldehydes (Angew. Chem. Int. Ed. 51/2008)
The inverse-electron-demand ... aza Diels–Alder reaction of N-sulfonyl-1-aza-1,3-butadienes and aldehydes shown in the cover picture is explored through catalysis by an α,α-diphenylprolinol OTMS ether salt. In their Communication on page 9971 ff., Y.-C. Chen and co-workers show how this simple process affords highly enantioenriched hemiaminal intermediates, which are readily converted into a diversity of chiral piperidine derivatives.
Also of Interest
H. Hopf describes applications of [2.2]paracyclophanes as monomers in his Minireview on page 9808 ff. Their layered structure can be retained or destroyed in novel polymers, and they can be used to prepare unsaturated molecular scaffolds.
Many natural products derive their biologically activity from sugar substituents; modification of the sugar structure can alter the properties of the parent compound. In their Review on page 9814 ff., H.-w. Liu et al. describe current research in glycodiversification.
The use Fourier transform ion cyclotron resonance mass spectrometery to investigate the reactivity of the σ,σ,σ-triradical 3,4,5-tridehydropyridinium cation is described by J. J.Nash, H. I. Kenttämaa, and co-workers in their Communication on page 9860 ff.