Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 31

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, Zeitschrift für Chemie

48_04b/2009Inside Cover: Site-Directed Asymmetric Quaternization of a Peptide Backbone at a C-Terminal Azlactone (Angew. Chem. Int. Ed. 4/2009)

A D2-symmetric chiral tetraaminophosphonium salt functions as an effective phase-transfer catalyst to achieve highly stereoselective alkylation of C-terminal azlactones of growing peptides, as described by T. Ooi and co-workers in their Communication on page 733 ff. The judicious combination of this method with a direct ligation process is a practical strategy for incorporating various chiral, non-racemic α,α-dialkyl-α-amino acids into a specific site of the peptide strand.

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