Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Inside Cover: A Synthetic Lectin for O-Linked β-N-Acetylglucosamine (Angew. Chem. Int. Ed. 10/2009)
Carbohydrates are slippery customers in water. Camouflaged by solvent-mimicking hydroxy groups, they make challenging targets, even for natural receptors. In their Communication on page 1775 ff., A. P. Davis and co-workers describe a synthetic receptor that is remarkably effective for the important β-N-acetylglucosaminyl (β-GlcNAC) unit. The affinities of the receptor are good and its selectivities are excellent, even by the standards of natural carbohydrate-binding proteins.