Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 44

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

48_18/2009Cover Picture: Direct C-H Metalation with Chromium(II) and Iron(II): Transition-Metal Host / Benzenediide Guest Magnetic Inverse-Crown Complexes (Angew. Chem. Int. Ed. 18/2009)

Chromation and ferration are the latest additions to the concept of alkali-metal-mediated metalation, as described by J. Klett, R. E. Mulvey, and co-workers in their Communication on page 3317 ff. While the more electropositive sodium is essential for the reaction, it is the less electropositive chromium or iron that actually performs deprotonation of benzene. This novel reactivity can be likened to a game of chess in which the queen (Na) holds the king in check, while the knight (Cr, Fe) scores checkm(etal)ate.

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Also of Interest

Synthesis of chemical librariesfor001

Natural product inspired chemical libraries are promising sources of new medicinally active ingredients. In their Minireview on page 3224 ff., K. Kumar and H. Waldmann outline how multistep methods established for the total synthesis of natural products can be adapted for chemical libraries.

Two-Photon Dyesfor002

R. G. Denning, H. L. Anderson, and co-workers describe in their Review on page 3244 ff. how the application of two-photon absorption processes can facilitate many areas. What principles should be considered in the development of such chromophores?

microRNA Detectionfor003

As little as a one-nucleotide difference among related microRNA sequences can be detected by the highly sensitive method reported by Z. Li et al. in their Communication on page 3268 ff. This method also has potential for in situ detection in specific tissues.