Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Inside Cover: Matrix-Free Formation of Gas-Phase Biomolecular Ions by Soft Cluster-Induced Desorption (Angew. Chem. Int. Ed. 23/2009)
Mass spectrometry of biomolecules has developed into a key technology in bioanalytics. As described by C. R. Gebhardt, M. Dürr et al. in their Communication on page 4162 ff., surface collisions of neutral molecular clusters can be used for soft formation of the required gas-phase biomolecular ions. Upon impact on a surface, the clusters provide the energy for desorption of the adsorbed biomolecules and serve as a transient matrix. Subsequent evaporative cooling prevents shattering and finally leads to an isolated biomolecular ion in the gas phase.