Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Breaking the Dogma of the Metal-Coordinating Carboxylate Group in Integrin Ligands: Introducing Hydroxamic Acids to the MIDAS To Tune Potency and Selectivity (Angew. Chem. Int. Ed. 24/2009)
The binding of the carboxyl group of an aspartate residue in the metal-ion-dependent adhesion site (MIDAS) is a key feature in the binding of ligands to integrins. This finding was demonstrated by the binding of the cyclic pentapeptide cyclo(RGDfNMeV) (Cilengitid) to the integrin αvβ3 (see picture). In their Communication on p. 4436 ff, H. Kessler and co-workers show that the carboxyl group previously considered essential for binding can be replaced by a hydroxamic acid unit.
Also of Interest
Catalysis in Water
In their Minireview on p. 4288 ff. J. Mlynarski and co-workers describe applications of amino acids and their derivatives as sources of chiral information in asymmetric catalytic conversions in aqueous media.
In their Review on page 4300 ff., K. S. Schanze, J. R. Reynolds, and co-workers discuss conjugated polyelectrolytes. The synthesis of these polymers is described, and some of their numerous applications are given.
The high-resolution structures of a complex foldamer in connection with its target is presented by W. D. Fairlie, S. H. Gellman, and co-workers in their Communication on p. 4318 ff. The structure provides information on the interaction of foldamers with their partners.