Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 40

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

48_27/2009Cover Picture: Polyketide-Chain Branching by an Enzymatic Michael Addition (Angew. Chem. Int. Ed. 27/2009)

The fungus Rhizopus microsporus ...; shown in the micrograph on the cover picture, harbors the endosymbiotic bacteria Burkholderia rhizoxinica that produces the antimitotic polyketide macrolide rhizoxin (see structure). In their Communication on page 5001 ff., C. Hertweck and co-workers show that the enzyme rhizoxin polyketide synthase is uniquely capable of introducing a β branch (highlighted by the magnifying glass) by a Michael-type addition of a malonyl unit to an acryloyl intermediate.

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Also of Interest

Metal-Free Click Reactionsfor001

In the Minireview on page 4900 ff., U. S. Schubert et al. demonstrate how far metal-free click chemistry has developed. Can Michael additions as well as Diels–Alder and thiol-ene reactions match the success of copper-catalyzed cycloadditions.

Heterogeneous Catalystsfor002

A catalyst particle might be assumed to be a mostly homogeneous solid. B. M. Weckhuysen explains that this is not the case in the Review on page 4910 ff. Channels, phase boundaries, and crystallite boundaries determine the diffusion of substrate molecules to the active centers inside the catalyst on the micro- and nanometer scale.

Affinity Agentsfor003

A nanomolar protein capture agent against carbonic anhydrase II was assembled using in situ click chemistry and the one-bead one-compound peptide library method, as described by J. R. Heath, K. B. Sharpless, and co-workers in their Communication on page 4944 ff.