Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Inside Cover: Charge-Conversional Polyionic Complex Micelles—Efficient Nanocarriers for Protein Delivery into Cytoplasm (Angew. Chem. Int. Ed. 29/2009)
A highly efficient protein delivery into cytoplasm is described by K. Kataoka, and co-workers on page 5309 ff. The charge-density increase of a protein cargo by reversible modification, which was based on the charge-conversional moieties citaconic amide and cis-aconitic amide, helped the stability of protein/block copolymer polyionic complex (PIC) micelles. The rapid protein charge conversion in endosomes induced the dissociation of the PIC micelles and efficient endosomal escape.