Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 6

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

48_29b/2009Inside Cover: Charge-Conversional Polyionic Complex Micelles—Efficient Nanocarriers for Protein Delivery into Cytoplasm (Angew. Chem. Int. Ed. 29/2009)

A highly efficient protein delivery into cytoplasm is described by K. Kataoka, and co-workers on page 5309 ff. The charge-density increase of a protein cargo by reversible modification, which was based on the charge-conversional moieties citaconic amide and cis-aconitic amide, helped the stability of protein/block copolymer polyionic complex (PIC) micelles. The rapid protein charge conversion in endosomes induced the dissociation of the PIC micelles and efficient endosomal escape.

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