Angewandte Chemie International Edition
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: An Enantiomerically Pure Alleno-Acetylenic Macrocycle: Synthesis and Rationalization of Its Outstanding Chiroptical Response (Angew. Chem. Int. Ed. 30/2009)
Enantiopure, Shape-Persistent alleno-acetylenic macrocycles are prepared from optically pure 1,3-diethynylallene building blocks, as F. Diederich et al. report in their Communication on page 5545 ff. These macrocycles with their crown geometry and chiral C28 backbone are not only aesthetically pleasing, they also display unusually intense Cotton effects in their circular dichroism spectra, which arise from the unique interplay of the shape-persistent geometry and electronic properties.
Also of Interest
Controlling Cell Function
Substrate nanotopography greatly influences cell behavior. In the Minireview on page 5406 ff., C. J. Bettinger, R. Langer, and J. T. Borenstein describe recent efforts to engineer synthetic substrates to control complex cell function.
A. V. Kabanov and S. V. Vinogradov report in their Review on page 5418 ff. the ability of nanogels to transport and release drugs and biomacromolecules. Their preparation and properties are described.
In their Communication on page 5430 ff., H. Xia and co-workers describe the unprecedented formal [4+2] cycloaddition reaction between a 1-metalla-1,3-diene and a nitrile, which affords examples of late-transition-metal-containing metallapyridine and metallapyridinium.