Angewandte Chemie International Edition
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Inside Cover: Addition Reactions of Sulfonylimidates with Imines Catalyzed by Alkaline Earth Metals (Angew. Chem. Int. Ed. 32/2009)
Addition reactions of sulfonylimidates to imines have been successfully catalyzed by alkali earth metal alkoxide salts, which are abundant, inexpensive, and nontoxic. As S. Kobayashi et al. show in their Communication on page 5927 ff., diastereoselectivity is highly dependent on solvents and catalysts: Reactions in DMF proceed with anti selectivity regardless of whether 1,8-diazabicyclo[5.4.0]undec-7-ene or a metal alkoxide is used as catalyst. In THF, syn products can be obtained using a metal alkoxide.