Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Achieving Molecular Complexity by Organocatalytic One-Pot Strategies—A Fast Entry for Synthesis of Sphingoids, Amino Sugars, and Polyhydroxylated α-Amino Acids (Angew. Chem. Int. Ed. 37/2009)
The gearing of an organocatalyzed chiral leaving group multiple cascade reaction strategy achieved molecular complexity in an efficient manner. As described by K. A. Jørgensen and co-workers in their Communication on page 6844 ff., the biologically inspired reaction led to 4,5-disubstituted isoxazoline-N-oxide products; the versatility of such building blocks is exemplified by the de novo syntheses of Ribo-phytosphingosine, an amino sugar, and polyfunctionalized α-amino acid derivatives.
Also of Interest
Radical enzymes allow reaction pathways that are not possible with two-electron steps. W. Buckel describes, in his Minireview on page 6779 ff., new synthetic methods with enzyme mechanisms which are based on the recycling of a radical or an electron.
Sensors Based on Viruses
Viruses—particularly bacteriophages—can be genetically modified to present foreign proteins on their surfaces. C. B. Mao and co-workers describe in their Review on page 6790 ff. how such viruses can be used as probes in sensors.
Ammonia–borane is a potential H2-releasing fuel for the hydrogen economy. In the Communication on page 6812 ff., D. A. Dixon, J. C. Gordon, et al. describe a method for regenerating polyborazylene, the predominant product of ammonia borane dehydrogenation.