Angewandte Chemie International Edition
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Inside Cover: Ultrasensitive and Selective Colorimetric DNA Detection by Nicking Endonuclease Assisted Nanoparticle Amplification
The ultrasensitive and selective colorimetric detection of DNA sequences is reported by X. Liu and co-workers in their Communication on page 6817 ff. The novel and versatile approach is based on a combination of an endonuclease nicking reaction and nanoparticle amplification. The approach can be utilized to detect ultralong (e.g., 80-mer) oligonucleotides with single base mismatch selectivity and a 1000-fold improvement in amplification, without complex procedures involving expensive instrumentation.