Angewandte Chemie International Edition
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Inside Cover: Switching the Chirality of the Metal Environment Alters the Coordination Mode in Designed Peptides (Angew. Chem. Int. Ed. 40/2009)
As switching railway points alter the course of an approaching train, switching the chirality of a single residue in the interior of a de novo designed three-stranded coiled coil dramatically alters the metal-binding capability of the peptide and the resulting position and coordination environment of the metal ion. The Communication by Pecoraro et al. on page 7371 ff. explores the binding of CdII to the L and D enantiomers of thiol-containing penicillamine through spectroscopic studies in solution and X-ray crystallography.