Angewandte Chemie International Edition

Cover image for Vol. 57 Issue 8

Editor: Neville Compton, Deputy Editor: Frank Maass. Editor Emeritus: Peter Gölitz

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

48_42/2009Cover Picture: Synthesis of Cyclopamine Using a Biomimetic and Diastereoselective Approach (Angew. Chem. Int. Ed. 42/2009)

A biomimetic synthesis of the potent anticancer drug cyclopamine that features a C-H activation/hydroxylation and a ring contraction/expansion is described by A. Giannis and co-workers in their Communication on page 7911 ff. The picture shows the structure of cyclopamine, the first inhibitor of hedgehog signaling (discovered in drosophilia); Veratrum californicum; a cyclopic sheep; and Homer, who first reported a cyclops in the Odyssey.

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Also of Interest

Protein Biochipsfor001

In their Minireview on page 7744 ff., C. M. Niemeyer, H. Waldmann, and co-workers examine the state of the art of the application of protein-biochip technology in biomedical and biotechnological research.


Graphenefor002

The latest research on the synthesis and characterization of graphene is presented by C. N. R. Rao et al. in their Review on page 7752 ff. Particular attention is paid to the physical properties of graphene and potential applications.


Highly Conductive Oxidesfor003

A molecular Sn/In precursor can be used to prepare tin-rich indium tin oxide, as described by M. Driess and Y. Aksu in the Communication on page 7779 ff. The resulting material is highly conductive, transparent, and remarkably stable.


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