Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 35

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

48_43/2009Cover Picture: Expedient Synthesis of N-Fused Indoles: A C-F Activation and C-H Insertion Approach (Angew. Chem. Int. Ed. 43/2009)

N-Fused indoles appear in the structures of various biologically active molecules, but synthesis of the fused-ring substructure has proved difficult. T. Akiyama and co-workers describe in their Communication on page 8070 ff. a new route in which a niobium carbenoid is generated by niobium-catalyzed activation of the normally inactive C–F bonds of a CF3 group. The carbenoid then undergoes insertion into a neighboring C(sp3)-H bond adjacent to a nitrogen atom to furnish the N-fused indole skeleton.

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