Angewandte Chemie International Edition
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Inside Cover: Protein Scaffold Engineering Towards Tunable Surface Attachment (Angew. Chem. Int. Ed. 49/2009)
Protein engineering holds the key to control, predict, and manipulate bio-inspired scaffolds on specific surfaces. In their Communication on page 9290 ff., D. Porath, O. Shoseyov, and co-workers describe selective, controlled, and tunable attachment of proteins to metal or insulating surfaces. SP1, a recently discovered ring-shaped protein, was genetically engineered to expose multiple binding sites simply by changing solvent conditions. Protein monolayers are created with no need for surface modifications.