Angewandte Chemie International Edition
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Inside Cover: Sensitive Detection of Native Proteins Using Extractive Electrospray Ionization Mass Spectrometry (Angew. Chem. Int. Ed. 17/2010)
Characterization of native proteins can be undertaken with extractive electrospray ionization mass spectrometry (EESI-MS). As H. Chen and co-workers describe in their Communication on page 3053 ff., EESI deposits charges on native proteins, which are separated from any high electric field. This method facilitates mass spectrometry, even from raw biological samples, without significant conformational changes or reduction in activity.