Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Label-Free Imaging of Metal–Carbonyl Complexes in Live Cells by Raman Microspectroscopy (Angew. Chem. Int. Ed. 19/2010)
The metal–CO vibration of the biologically active complex [Mn(tpm)(CO)3]+ (tpm=tris(1-pyrazolyl)methane) has been used to study its distribution in living cancer cells. In their Communication on page 3310 ff., N. Metzler-Nolte, M. Havenith, and co-workers show that the intrinsic spectroscopic signature of the manganese carbonyl complex enables it to be localized in cells by using Raman microspectroscopy. 3D Raman intensity images show that the complex is accumulated in the nuclear membrane and the nucleolus.
Also of Interest
Gold nanoparticles modified with monolayers of different ligands self-assemble with fluorescent probes through electrostatic effects. U. H. F. Bunz and V. M. Rotello describe in their Minireview on page 3268 ff. how these constructs are used as biosensors.
As their surfaces can be modified almost at will with biologically active molecules, gold nanoparticles are promising for many applications in medicine and diagnostics. C. A. Mirkin present some examples in their Review on page 3280 ff.
Silicon–Metal Triple Bonds
In their Communication on page 3296 ff., A. Filippou and co-workers describe the transfer of a N-heterocyclic carbene from a molybdenum silylidene complex to a triarylborane to form the first metal–silylidyne complex.