Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Inside Cover: In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice (Angew. Chem. Int. Ed. 19/2010)
Inverse-electron-demand Diels–Alder reactions can be performed efficiently in a living animal. In their Communication on page 3375 ff., M. S. Robillard and co-workers report a 52 % yield in vivo between a tumor-localized antibody carrying trans-cyclooctene tags and a 111In-labeled tetrazine probe. The rapid reaction of the chemically tagged tumors with the probe resulted in pronounced radioactivity localization in the tumor, as demonstrated by non-invasive imaging of live mice.