Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Inside Cover: The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain (Angew. Chem. Int. Ed. 37/2010)
Sea snails of the Conus genus produce bioactive peptides in their venoms to capture prey, but chemists can re-engineer these peptides for drug-design purposes. In their Communication on page 6545 ff., D. J. Craik and co-workers describe how the chemical cyclization of a peptide from Conus victoriae was used to produce a stable and orally active drug lead that is a potent analgesic in a rat model of neuropathic pain. Image design: David Wilson.