Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 5

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

49_37b/2010Inside Cover: The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain (Angew. Chem. Int. Ed. 37/2010)

Sea snails of the Conus genus produce bioactive peptides in their venoms to capture prey, but chemists can re-engineer these peptides for drug-design purposes. In their Communication on page 6545 ff., D. J. Craik and co-workers describe how the chemical cyclization of a peptide from Conus victoriae was used to produce a stable and orally active drug lead that is a potent analgesic in a rat model of neuropathic pain. Image design: David Wilson.

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