Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Palladium-Catalyzed Coupling of Aldehyde-Derived Hydrazones: Practical Synthesis of Triazolopyridines and Related Heterocycles (Angew. Chem. Int. Ed. 45/2010)
Pharmaceutically active compounds ... ... and their intermediates require selective, efficient, and robust syntheses that utilize green chemistry principles. In their Communication on page 8395 ff., O. R. Thiel, M. Achmatowicz, and co-workers describe a two-step procedure involving selective palladium-catalyzed carbon–nitrogen bond formation followed by a clean oxidative cyclization that affords access to a variety of bicyclic and tricyclic heteroaromatic scaffolds.
Also of Interest
In his Review on page 8328 ff., A. Thomas gives an overview of the area of porous organic–inorganic and organic functional materials, with a focus on materials in which functional groups are incorporated as a supporting part of the pore walls.
Solid-State NMR Spectroscopy
Recent advancements in NMR techniques, biophysics, and molecular biology have expanded the repertoire of solid-state NMR spectroscopy for biomolecular studies. In their Review on page 8346 ff., M. Baldus et al. consider the status of the technique with a view to future applications.
NMR Spectroscopic Signal Enhancement
H. W. Spiess and co-workers show in their Communication on page 8358 ff. how parahydrogen-induced polarization can be used for the continuous generation of hyperpolarized molecules with hollow-fiber membranes.