Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 49

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

49_47/2010Cover Picture: The AlkB Domain of Mammalian ABH8 Catalyzes Hydroxylation of 5-Methoxycarbonylmethyluridine at the Wobble Position of tRNA (Angew. Chem. Int. Ed. 47/2010)

tRNA Hypermodification by mammalian ABH8 is described by C. He, T. Pan, and co-workers in their Communication on page 8885 ff. The mammalian AlkB homologue ABH8, containing an AlkB dioxygenase domain, catalyzes the oxidation of mcm5U into (S)-mchm5U at the wobble position (uridine) in tRNA.

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Also of Interest

Isoprenoid Biosynthesisfor001

Based on X-ray structure analyses of IspH proteins, a mechanism for the last step in the non-mevalonate biosynthesis of isopentenyl diphosphate and dimethylallyl diphosphate is describe M. Groll, T. Gräwert et al. in their Minireview on page 8802 ff.

Stable Cyclic Carbenesfor002

In their Review on page 8810 ff. G. Bertrand et al. describe the synthesis and characterization of stable cyclic carbenes. The stability, electronic properties, coordination behavior, and catalytic activity of these complexes are also described.

Catalytic C-H Functionalizationfor003

T. R. Cundari, T. H. Warren, and co-workers describe in their Communication on page 8850 ff. a three-coordinate copper(II) amide that allows for the catalytic amination of C(sp3)-H bonds with unactivated primary and secondary amines.