Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: The AlkB Domain of Mammalian ABH8 Catalyzes Hydroxylation of 5-Methoxycarbonylmethyluridine at the Wobble Position of tRNA (Angew. Chem. Int. Ed. 47/2010)
tRNA Hypermodification by mammalian ABH8 is described by C. He, T. Pan, and co-workers in their Communication on page 8885 ff. The mammalian AlkB homologue ABH8, containing an AlkB dioxygenase domain, catalyzes the oxidation of mcm5U into (S)-mchm5U at the wobble position (uridine) in tRNA.
Also of Interest
Based on X-ray structure analyses of IspH proteins, a mechanism for the last step in the non-mevalonate biosynthesis of isopentenyl diphosphate and dimethylallyl diphosphate is describe M. Groll, T. Gräwert et al. in their Minireview on page 8802 ff.
Stable Cyclic Carbenes
In their Review on page 8810 ff. G. Bertrand et al. describe the synthesis and characterization of stable cyclic carbenes. The stability, electronic properties, coordination behavior, and catalytic activity of these complexes are also described.
Catalytic C-H Functionalization
T. R. Cundari, T. H. Warren, and co-workers describe in their Communication on page 8850 ff. a three-coordinate copper(II) amide that allows for the catalytic amination of C(sp3)-H bonds with unactivated primary and secondary amines.