Angewandte Chemie International Edition
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Inside Cover: A Potent Trans-Diimine Platinum Anticancer Complex Photoactivated by Visible Light (Angew. Chem. Int. Ed. 47/2010)
Photoactivation can be used to activate anticancer drugs selectively just at the site of a tumor. Such targeted treatments promise fewer side effects and may address the problem of acquired resistance associated with drugs such as cisplatin. P. J. Sadler and co-workers show in their Communication on page 8905 ff. that the octahedral complex trans,trans,trans-[PtIV(N3)2(OH)2(py)2] is potentially cytotoxic towards a number of cell lines when activated by blue light, with no toxicity in the absence of irradiation.