Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Backside Cover: Remote Supramolecular Control of Catalyst Selectivity in the Hydroformylation of Alkenes (Angew. Chem. Int. Ed. 2/2011)
The precise control of selectivity is one of the most challenging issues in transition-metal catalysis. As reported in their Communication on page 396 ff., J. N. H. Reek and co-workers have applied a supramolecular design strategy to preorganize alkene substrates for selective rhodium-catalyzed hydroformylation reactions. A catalyst equipped with an anion-binding pocket interacts with alkenes that contain anionic functionalities to exert high control over the regioselectivity of the transformation.