Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 5

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

50_05/2011Cover Picture: Biocatalytic Enantioselective Oxidative C-C Coupling by Aerobic C-H Activation (Angew. Chem. Int. Ed. 5/2011)

Berberine bridge enzyme (BBE) from the California poppy enantioselectively converts benzylisoquinolines into berbines by oxidative C-C coupling that consumes O2 as a stoichiometric oxidant. In their Communication on page 1068 ff., W. Kroutil and co-workers describe the first biocatalytic application of BBE on a preparative scale. Novel optically pure benzylisoquinolines and berbines were prepared by BBE-catalyzed oxidative kinetic resolution of racemic substrates. Cover picture by V. Resch.

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Also of Interest

Photochemical Reactionsfor001

Synthetic chemists have often been reluctant to use photochemical reactions in organic synthesis. T. Bach and J. P. Hehn show in their Review on page 1000 ff. that this reserve is unfounded by highlighting the most important photochemical transformations that have been employed in natural product synthesis.

Cage Compoundsfor002

In their Communication on page 1046 ff., M. Mastalerz and co-workers describe a functionalized cage compound with exceptionally high surface area and remarkable gas-adsorption properties.


M. von Itzstein and co-workers describe in their Communication on page 1055 ff. how a-GM3 (α-2,3-sialyllactose) binds to the rotavirus surface protein VP8* with both the sialic acid and galactose moieties contributing to the binding event.