Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Inside Cover: Microfluidic Multicolor Encoding of Microspheres with Nanoscopic Surface Complexity for Multiplex Immunoassays (Angew. Chem. Int. Ed. 5/2011)
Transparent microspheres can be optically encoded with color core droplets, as shown by S.-H. Kim, J. W. Shim, and S.-M. Yang in their Communication on page 1171 ff. A microfluidic device produces and manipulates double-emulsion droplets containing the desired number of color core droplets with unprecedented controllability. The droplets are then photopolymerized to produce microspheres. Silica particle arrays on the surface of the encoded microspheres enable biomolecules to be immobilized.