Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 27

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

50_07i/2011Inside Cover: Lewis Acid Activated Synthesis of Highly Substituted Cyclopentanes by the N-Heterocyclic Carbene Catalyzed Addition of Homoenolate Equivalents to Unsaturated Ketoesters (Angew. Chem. Int. Ed. 7/2011)

A highly diastereo- and enantioselective N-heterocyclic carbene catalyzed/titanium(IV)-mediated homoenolate addition to β,γ-unsaturated α-ketoesters to assemble cyclopentanols with four contiguous stereogenic centers is described by Scheidt and co-workers in their Communication on page 1678 ff. The Lewis acid is essential for the reaction and a wide range of β,γ-unsaturated α-ketoesters and enals are tolerated, with the products obtained in 52–85% yield and up to 99% ee.

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