Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 28

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

50_12i/2011Inside Cover: One-Pot High-Yielding Synthesis of the DPP4-Selective Inhibitor ABT-341 by a Four-Component Coupling Mediated by a Diphenylprolinol Silyl Ether (Angew. Chem. Int. Ed. 12/2011)

The dipeptidyl peptidase IV selective inhibitor ABT-341 was synthesized by an uninterrupted sequence of reactions in excellent yield with excellent diastereo- and enantioselectivity. Y. Hayashi et al. describe in their Communication on page 2824 ff. how a diphenylprolinyl silyl ether mediates the sequence of an asymmetric Michael reaction, a domino Michael/Horner–Wadsworth–Emmons reaction combined with a retro-aldol reaction, a base-catalyzed isomerization, an amide bond formation, and a reduction of the nitro group to an amine.

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