Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 23

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

50_19/2011Cover Picture: Proton-Detected Solid-State NMR Spectroscopy of Fibrillar and Membrane Proteins (Angew. Chem. Int. Ed. 19/2011)

Solid-state NMR spectroscopy has recently emerged as a tool for structural biology. Sensitivity and resolution, however, still hamper more widespread applications. Protons are ideal as they have the largest gyromagnetic ratio, but they can induce severe line broadening. As described in the Communication by B. Reif and co-workers on page 4508 ff., perdeuteration and partial back-substitution of exchangeable protons can overcome the strong coupling problem. The approach is successfully implemented for fibrils and membrane proteins.

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Film Formation by Click Chemistryfor002

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