Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 50

Editor: Neville Compton; Editor Emeritus: Peter Gölitz

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

50_22i/2011Inside Cover: Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins (Angew. Chem. Int. Ed. 22/2011)

Amyloid peptide fibrillation causes many neurodegenerative disorders including Alzheimers disease. Some drugs can inhibit this process by binding to peptides in a 1:1 ratio. In their Communication on page 5110 ff., N. A. Kotov et al. describe the inhibition efficacy of nanoparticles (NPs), which bind to peptide oligomers. The mechanism of NP inhibition is similar to that of proteins responsible for preventing amyloid fibrillation in the human body.

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