Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Diastereoselective Total Synthesis of (±)-Schindilactone A (Angew. Chem. Int. Ed. 32/2011)
A traditional Chinese herbal medicine schindilactone A, has been synthesized for the first time by Y.-F. Tang, J.-H. Chen, Z. Yang, and co-workers. In their Communication on page 7373 ff., they outline an approach involving ring-closing metathesis for diastereoselective formation of the fully functionalized eight-membered CDE rings, a thiourea/cobalt-catalyzed Pauson–Khand reaction for the stereoselective construction of the F ring, and a thiourea/palladium-catalyzed carbonylative annulation cascade to construct the GH rings.
Also of Interest
Catalytic Water Splitting
Established systems that split water to form hydrogen are based on noble-metal catalysts. In their Review on page 7238 ff., M. Fontecave et al. present systems that use cobalt compounds, which achieve this task preferentially in a photocatalytic process with (sun)light as the energy source.
In their Communication on page 7268 ff., H.-A. Wagenknecht and C. Holzhauser introduce a molecular beacon with color readout. Energy transfer between two chromophores in the DNA stem architecture yields a red fluorescence that changes to green upon binding to the target oligonucleotide sequence.
In their Communication on page 7329 ff., J.-H. Xie, Q.-L. Zhou, and co-workers describe an exceptionally active and highly enantioselective chiral iridium catalyst for ketone hydrogenation.