Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 4

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

50_38b/2011Back Cover: Tuning DNA Stability To Achieve Turnover in Template for an Enzymatic Ligation Reaction (Angew. Chem. Int. Ed. 38/2011)

Unlike native DNA a DNA template containing a destabilizing modification dissociates from the templated ligation product after its formation. As reported by J. M. Gibbs-Davis et al. in their Communication on page 8922 ff., such destabilizing templates turn over in enzymatic ligation reactions, thereby leading to multiple strands per template. Consequently, isothermal DNA amplification and even replication can be achieved using ligase, simple destabilizing modifications, and standard DNA functional groups.

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