Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 31

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

50_42b/2011Back Cover: Development of Highly Cytotoxic and Actin-Depolymerizing Biotin Derivatives of Aplyronine A (Angew. Chem. Int. Ed. 42/2011)

Aplyronine A is an antitumor macrolide from the sea hare Aplysia kurodai. In their Communication on page 9871 ff., H. Kigoshi and co-workers report the synthesis of a poly(ethylene glycol) (PEG)-linked derivative of aplyronine A, which exhibits potent cytotoxicity and can cause actin disassembly in tumor cells. Actin-related proteins as well as actin were specifically purified from cell lysate by using this probe.

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