Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Back Cover: Development of Highly Cytotoxic and Actin-Depolymerizing Biotin Derivatives of Aplyronine A (Angew. Chem. Int. Ed. 42/2011)
Aplyronine A is an antitumor macrolide from the sea hare Aplysia kurodai. In their Communication on page 9871 ff., H. Kigoshi and co-workers report the synthesis of a poly(ethylene glycol) (PEG)-linked derivative of aplyronine A, which exhibits potent cytotoxicity and can cause actin disassembly in tumor cells. Actin-related proteins as well as actin were specifically purified from cell lysate by using this probe.