Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Inside Cover: Magnesium-Mediated Benzothiazole Activation: A Room-Temperature Cascade of C-H Deprotonation, C-C Coupling, Ring-Opening, and Nucleophilic Addition Reactions (Angew. Chem. Int. Ed. 42/2011)
A special type of N-heterocycle activation promoted by a main-group compound is described by E. Hevia and co-workers in their Communication on page 9857 ff. Whereas previous organomagnesium reagents simply deprotonate benzothiazole, a new sodium magnesiate modification incorporating a bulky bis(amido) ligand initiates an unstoppable domino reaction that involves direct Mg-H exchange, C-C coupling, ring opening, nucleophilic addition, and intramolecular deprotonation of three molecules of benzothiazole at room temperature.