Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 35

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, Zeitschrift für Chemie

50_47/2011Cover Picture: High-Throughput In Vitro Glycoside Hydrolase (HIGH) Screening for Enzyme Discovery (Angew. Chem. Int. Ed. 47/2011)

Glycoside hydrolase screening is possible by coupling enzyme expression with enzyme activity in one pot. In their Communication on page 11 215 ff., H. W. Blanch, D. S. Clark et al. describe a high-throughput in vitro glycoside hydrolase screening method, in which the cell-free expression of glycoside hydrolases is powered by monosaccharides. The method enables screening of the activity of cellulases or xylanases on insoluble substrates directly from the DNA that encodes these enzymes.

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Also of Interest

Copper-Catalyzed Aerobic Oxidationsfor001

The selective oxidation of C-H bonds and the use of O2 as an oxidant represent two prominent challenges in organic chemistry. S. S. Stahl and co-workers summarize in their Review on page 11 062 ff. how many of these reactions can be rendered catalytic in copper.


α-Ketoamidesfor002

A novel copper-catalyzed aerobic oxidative coupling of aryl acetaldehydes with anilines is described by N. Jiao et al. in their Communication on page 11 088 ff. The reaction involves the cleavage of two Csp3-H bonds as well as one Csp2-H and one N-H bond.


Fuel Cells

In their Communication on page 11 202 ff., S. Ogo and co-workers describe a complete fuel cell based on a molecular [NiFe]hydrogenase mimic. The complex catalyzes the oxidation of H2 to protons and functions in both solid and solution phases.

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